When an opioid analgesic is currently being discontinued resulting from a suspected substance use problem, patients should be evaluated and treated, or referred for analysis and procedure of the substance use disorder; therapy really should include things like evidence-centered techniques, including

Elderly and really ill individuals can maybe practical experience apnea or cardiac arrest. Concomitant use of other central nervous process depressants raises this hazard. The smallest doable successful dose really should be used for this team of men and women.[fifty nine][sixty] The elderly metabol